Now that you know the causes of your issue, it is time for you to put light on the solutions to the dilemma.
Copying of old OST file used by the previous outlook version after upgrading. Change in the location of the OST file stored in the machine. Incorrect configuration of outlook profile. The outlook profile is not tested properly. The current outlook profile is corrupted. The outlook data file is not stored in the right place. After the research of diverse cases, some primary causes of the issue "outlook data file cannot be opened" are elaborated below. This is not it there could to different scenarios that should be held accountable for this issue. The causes are not that complex to understand for the user. These factors include virus attacks, overgrown size of the file, and accidental shutdowns. 
The outlook data file being damaged could be the result of various factors. Why Outlook data file cannot be opened error occurred?
Tip 8: Automatic solution: stellar repair for outlook. Tip 6: Fix outlook hanging on loading profile. Tip 3: Recover the Navigation pane configuration file. Tip 2: Set outlook profile via an Auto account set up in outlook. Tip 1: Create a new Outlook profile and import data from the old PST file. Why Outlook data file cannot be opened error occurred?. If you have feedback for TechNet Subscriber Support, Click here to learn more. Please remember to mark the replies as answers if they helped. Exit Outlook and go to Control Panel > Indexing Options > Advanced > Rebuild.Īny updates, please feel free to post back. In this case, please rebuild index to check the results. When running Outlook in safe mode, Instant Search functionality in Outlook (that is provided by WDS) is disabled. Choose the data file and click Open File Locations. 
To check the location of your Outlook Data Files in Outlook, please select File > Account Settings > Account Settings. A new data file will be created automatically. For Exchange account, we can rename the old data files to. We can first repair Outlook data files(ost) to see if it helps. When Exchange account is using cached Exchange mode, it uses Windows Desktop Search to search messages.
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